Current Research

There are many excellent reference articles on the subject of sleep disorders. Below we list some examples. Dr. Hussain has collaborated in writing a book and several articles in his chosen field of specialization.

Books

“CONQUERING INSOMNIA – a Patient’s Guide to Sleep Disorders” – Shapiro, C. M.; MacFarlane, James; Hussain, M. R. G. – Empowering Press, Hamilton, Canada, 1994

First-Authored Articles

Considerations and possible consequences of shift-work. – Hossain JL, Shapiro CM. Journal of Psychosomatic Research, 1999; 47 (4):293-296.

The Prevalence, Cost Implications and Management of Sleep Disorders: An Overview. – Hossain JL, Shapiro CMSleep and Breathing 2002; 6 (2): 85-102.

Underlying sleep pathology may cause chronic high fatigue in shift-workers.
– Hossain JL, Reinish LW, Kayumov L, Bhuiya P, Shapiro CM. Journal of Sleep Research 2003; 12:223-230.

Subjective and objective evaluation of sleep and performance in daytime versus nighttime sleep in extended hours shift-workers at an underground mine. – Hossain JL, Reinish LW, Heslegrave RJ, Hall GW, Kayumov L, Chung SA, Bhuiya P, Jovanovic D, Huterer N, Volkov J, Shapiro CM. Journal of Occupational and Environmental Medicine 2004;46 (3): 212-226.

Subjective fatigue and subjective sleepiness: two independent consequences of sleep disorders? – Hossain JL, Ahmad P, Reinish RW, Kayumov L, Hossain NK, Shapiro CM. J Sleep Res. 2005 Sep;14(3):245-53.

Co-authored articles

“How, What, and Why of Sleep Apnea – Perspectives for Primary Care Physicians”
– Chung, Sharon; Jairam, Shani; Hussain, Mohamed R. G.; Shapiro, Colin M. – Canadian Family Physician 2002;48:1073-1080, Vol. 48, June 2002

“Knowledge of Sleep Apnea in a Sample Grouping of Primary Care Physicians”
– Chung, Sharon; Hussain, M. R. G. and Shapiro, C. M. – Sleep and Breathing. Vol.5, Number 3, 2001

“Hypnotics in Insomnia” – Hussain, M. R. G.; Shapiro, C. M. – Specialist Medicine,
March 1996

“What Every G.P Should Know from a Sleep Specialist” – Sue Ellin Holme; Hussain, M. R. G.; Shapiro, C. M. – American Polysomnographic Society, May 1995

“Sleep Problems in the Medically Ill” ABC of Sleep Disorders – Shapiro, C. M.; Devins, G.; Hussain, M.R.G. – British Medical Journal Publications, May 1993

Clinical Trials

Eisai Inc Research Protocol # Eisai E2006-304: A multicenter, randomized, double blind, placebo controlled, active comparator, parallel-group study of the efficacy and safety of Lemborexant in subjects 55 years and older wit Insomnia disorder

START DATE: November 2016
END DATE: March 2018

U Eye Laser Cosmetic, Brampton, Ontario, Canada Sponsored clinical research: Examining the relationship between Diabetic Macular Edema and Obstructive Sleep Apnea (DME-OSA)

START DATE: January 2017
END DATE: May 2017

Canadian Cardiovascular Research Network organized research project: 24 week open label, single arm study of Colesevelam in high risk south Asians with suboptimal LDL-c levels despite maximally tolerated statin therapy

START DATE: April 2016
END DATE: February 2017

INC Reasearch Protocol # DS5565-A-E312: An open-label extension study of DS-5565 for 52 weeks in pain associated with Fibromyalgia

START DATE: October 2015
END DATE: June 2017

INC Research Protocol # DS5565-A-E309: A randomized, double-blind, placebo- and active-controlled study of DS-5565 in subjects with pain associated with fibromyalgia.

START DATE: April 2014
END DATE: October 2015

Pfizer Study Protocol A0081245: A Phase 3 double-blind, randomized, placebo-controlled, safety and efficacy study of once daily controlled release pregabalin in the treatment of patients with fibromyalgia.

START DATE: November 2010
END DATE: December 2013

Pfizer Study Protocol A0081165: Effects of Pregabalin on sleep maintenance in subjects with fibromyalgia syndrome and sleep maintenance disturbance: A randomized placebo-controlled 2-way crossover polysomnography study.

START DATE: August 2009
END DATE: November 2010

Refinement of patient reported outcomes instruments in subjects with insomnia characterized by non-restorative sleep.

START DATE: 14 November, 2008
END DATE: 23 April, 2009

PD 0200390 Dose-ranging Trial: A randomized, double-blind, parallel group, placebo-controlled, multicenter outpatient trial of PD 0200390 in adults with primary insomnia.

START DATE: 04 January, 2008
END DATE: 20 March, 2009

A 28 day, polysomnographic and subjective assessment of GW679769, 10 and 30 mg, for the treatment of primary insomnia: A randomized, double-blind, parallel-group, placebo-controlled trial.

START DATE: March 2006
END DATE: May 2007

Other Articles

“Sleep-Related Breathing Disorders, Loud Snoring and Excessive Daytime Sleepiness in Obese Subjects” – Resta, O.; Foschino-Barbaro, M.P.; Legari, G.; Talamo, S.; Bonfitto, P. and Palumbo, A. – Int Obes Relat Metab Disord 2001;25(5):669-75

“Association of Sleep-Disordered Breathing, Sleep Apnea, and Hypertension in a Large Community-Based Sleep Heart Health Study” – Nieto, F.J.; Young, T.B.; Lind, B. K.; Shahar, E.; Samet, I. M. and Redline, S. – JAMA 2000:283(14):1829-36

“Primary Open-Angle Glaucoma is Associated with Sleep Apnea Syndrome” – Mojon, D. S. ; Hess, C. W.; Goldblum, D.; Bohnke, M.; Korner, F. and Mathis, J. – Ophthalmologica 2000;214(2):115-8

“Time Course of Sleep-Related Breathing Disorders in Firt-Ever Stroke or Transient Ischemic Attack” – Parra, O.; Arboix, A.; Bechich, S.; Garcia-Eroles, L.; Montserrat, J. M. and Lopez, J.A. – Am J Respir Crit Care Med 2000;161(2 Pt 1):375-80

“Association of Hypertension and Sleep-Disordered Breathing” – Bixler, F. O.; Vgontzas, A.N.; Lin, H.M.; Ten, Have T. ; Leiby, B. E. and Vela-Bueno, A. – Arch Intern Med 2000;160(15):2289-95

“Sleepiness, Fatigue, Tiredness, and lack of Energy in Obstuctive Sleep Apnea”
– Chervin, R.D. – Chest 2000:118:372-9

“Long-term Effects of Nasal Continuous Positive Airway Pressure on Daytime Sleepiness, Mood and Traffic Accidents in Patients with Obstructive Sleep Apnea”
– Yamamoto, H.; Akashiba, T.; Kosaka, N.; Ito, D. and Horie, T. – Respir Med 2000;94(1):87-90

“Sleep Apnea in Heart Transplant Recipients: Type, Symptoms, Risk Factors, and Response to Nasal Continuous Positive Air Pressure”– Brilakis, E. S.; Olson, E. J.; McGregor, C. G. and Olson, I. J. – J Heart Lung Transplant 2000;19(4):330-6

“Effects of a Mandibular Advancement Device for the Treatment of Sleep Apnea Syndrome and Snoring on Respiratory Function and Sleep Quality” – Yoshida, K. – Cranio 2000;18(2):98-105

“The Association Between Sleep Apnea and the Risk of Traffic Accidents. Cooperative Group Burgos-Santander” – Teran-Santos, ].; Jimenez-Gomez, A. and Cordero-Guevara, J . – N Engl J Med 1999;340(11):847-51

“Using the Berlin Questionnaire to Identify Patients at Risk for the Sleep Apnea Syndrome” – Netzer, N. C.; Stoohs, R.A.; Netzer, C. M.; Clark, K. and Strohl, K.E. – Ann Intern Med 1999:131 (7):485-91

“Obstructive Sleep Apnea as a Risk Marker in Coronary Artery Disease” – Schafer, H.; Koehler, U.; Ewig, S.; Hasper, E.; Tasci, S. and Luderitz, B. – Cardiology 1999;92(2):79-84

“Occult Sleep Apnea in a Recruited Sample of Older Adults with Insomnia” – Lichstein KL, Riedel, B.W., Lester, K.W. and Aguillard R.N. – J Consult Clin Psychol 1999;67(3):405-10

“Sleep-Disordered Breathing in Alcoholics” – Aldrich, M.S.; Brower, K. L. and Hall, J. M. – Alcohol Clin Exp Res 1999;23(1):134-40

“Health Care Utilization in Males with Obstructive Sleep Apnea Syndrome Two Years After Diagnosis and Treatment” – Bahammam, A.; Delaive, K.; Ronald, J.; Manfreda, J.; Roos, L. and Kryger, M. H. – Sleep 1999;22(6):7407.

“Sleep Apnea in Congestive Heart Failure” – Naughton, M. T.; Bradley, T. D.
– Clin Chest Med 1998;19(1):99-113

“Impact of Nasal Continuous Positive Airway Pressure Treatment on Quality of Life in Patients with Obstructive Sleep Apnea” – Bolitschek, J.; Schmeiser-Rieder, A.; Schobersberger, R.; Rosenberger, A.; Kunze, M. and Aigner, K. . – Eur Respir J 1998:11(4):890

“Obstructive Sleep Apnea and Diabetes Mellitus: The Role of Cardiovascular Autonomic Neuropathy” – Ficker, J. H.; Dertinger, S. H.; Siegfried, W.; Konig, H. J.; Pentz, M. and Sailer, D. – Eur Respir J 1998;11(1):14-9

“Sleep-Disordered Breathing and Neuropsychological Deficits” – Kim, H. C.; Young, T.; Mathews, C. O.; Weber, S. M.; Woodard, A. R. and Palta, M. – Am J Respir Crit Care Med 1997:156:1813-9

“Estimation of the Clinically Diagnosed Proportion of Sleep Aonea Syndrome in Middle Aged Men and Women” – Young, T.; Evans L.; Finn, L. and Palta, M. – Sleep 1997;20(9):705-6

“Erectile Dysfunction in Sleep Apnea and Response to CPAP” – Karacan, I. and Karatas, M. – J Sex Marital Ther 1995;21(4):239-47

“Smoking as a Risk Factor for Sleep-Disordered Breathing” – Wetter, D. W.; Young, T. B.; Bidwell, T. R.; Badr, M. S.; Palta, M. – Arch Intern Med 1994;154(19):2219-24

“Obstructive Sleep Apnea and Depression-Diagnostic and Treatment Implications” – Kaplan, R. – Aust N Z J Psychiatry 1992:26(4):586-91

“Association of Sleep Apnea with Myocardial Infarction in Men” – Hung, J.; Whitford, E. G.; Parsons, R. W. and Hillman, D. R. – Lancet 1990;336:261-4

“Weight Loss in Mildly to Moderately Obese Patients with Obstructive Sleep Apnea” – Smith, P. L.; Gold, A. R.; Meyers, D. A.; Haponik, E. F.; Bleecker E. R.- Ann Intern Med 1985;103(6 Pt 1):850-5